Now that the biggest political stories of the year have been ranked, inspected, and dissected, it’s science’s turn. Not all of the hundreds of thousands of research studies published this year produced far-reaching scientific breakthroughs, but a select few hold more promise than the rest.
Cancer research had the biggest year, according to the journal Science, which on Thursday released its list of the top 10 breakthroughs in scientific research of the year. Research several decades in the making on cancer immunotherapy, which targets the human immune system rather than tumors themselves, is finally producing promising results in clinical trials, the publication’s announcement explains. The new treatments harness the power of the immune system by pushing T cells and other disease-fighting cells to attack tumors.
Cancer immunotherapy still has a ways to go until it reaches the hospital room. Right now, the treatment works only for some cancers and a few patients, but many cancer specialists are convinced that this is the start of a new, game-changing chapter in cancer research. So do a number of pharmaceutical companies, which have begun investing heavily in immunotherapy research.
Here are the rest of this year’s biggest advances in research in the fields of “¦
Genetics. Discovered in bacteria, a gene-editing technique called CRISPR, which stands for Clustered Regularly Interspaced Short Palindromic Repeats, jumped to the operating table when researchers started using it to manipulate individual genes in the genomes of plant, animal, and human cells.
Alternative energy. A new kind of solar-cell material, called Perovskite cells, garnered attention because they are cheaper and easier to produce than what’s inside traditional silicon cells. They’re not yet as efficient as commercial solar cells, but once refined they could work twice as better.
Biology. Scientists used the structure of an antibody to design an immunogen, the main ingredient of vaccines, for a respiratory virus that sends millions of children younger than 5 to the hospital each year.
Neuroscience. A new imaging technique changed the way researchers studied the brain by rendering brain tissue transparent, making neurons and other types of cells more visible than ever before. The Stanford-developed technology, known as CLARITY, allows scientists to see a fully intact brain and its complex structures in all their three-dimensional glory. Many experiments on postmortem brains require cutting or slicing the organ to get a better look.
Anatomy. Researchers probably weren’t following the trend of creating miniature versions of everything, like teacup pigs, but they succeeded in growing mini-human-like “organoids” in vitro. The small organs, including liver buds, kidneys, and even brains, provide better models for studying human disease than their animal equivalents.
Space. After a century of speculation, scientists finally confirmed that cosmic rays, high-energy particles that can reach Earth from anywhere in space, originate from debris clouds left behind by exploding stars, called supernovae. Fun fact: Cosmic rays can shoot protons through space at energies thousands of times greater than those in the most powerful particle accelerator on Earth.
Stem cells. Researchers successfully derived stem cells from cloned human embryos. The key to this achievement was hiding just inside our coffee mugs: caffeine. The drug stabilized molecules in delicate human egg cells, allowing scientists to carefully extract stem cells.
Sleep. Mice studies revealed that the brain “cleans” itself much more efficiently after bedtime. During sleep, the organ expands the channels between neurons, which allows more cerebrospinal fluid, a colorless, protective fluid that cushions the brain inside the skull, to flow through. This helps the brain restore and repair itself after a hard day’s work of being awake. Moral of the study: Sleep is good for you.
Microbiology. Scientists concluded that humans can thank the old adage of “the whole is greater than the sum of its parts” for their well-being. Research on the trillions of bacterial cells that call the human body home revealed the crucial roles tiny microbes play in keeping us healthy. Turns out that microorganisms, the majority of which were labeled enemies of health and targeted for destruction, are actually our friends.
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Twenty-one states, the District of Columbia and several public interest groups filed the first major lawsuits Tuesday to block the repeal of the Federal Communications Commission’s net neutrality rules. The FCC's rules had prohibited Internet providers from slowing down or blocking websites. New York Attorney General Eric Schneiderman, who is leading the states' suit, said that the FCC’s repeal was “arbitrary” and “capricious” and violates federal law. The suit comes just a day after Democrats in the Senate said they were inching closer to acquiring the votes needed to pass legislation overturning the FCC's rule change. It has garnered the support of all 49 Democratic senators as well as one Republican, Sen. Susan Collins (R-ME).
"A former C.I.A. officer suspected of helping China identify the agency’s informants in that country has been arrested, the Justice Department said on Tuesday. Many of the informants were killed in a systematic dismantling of the C.I.A.’s spy network in China starting in 2010 that was one of the American government’s worst intelligence failures in recent years, several former intelligence officials have said. The arrest of the former agent, Jerry Chun Shing Lee, 53, capped an intense F.B.I. investigation that began around 2012 after the C.I.A. began losing its informants in China."
"Three-quarters of the members of a federally chartered board advising the National Park Service abruptly quit Monday night out of frustration that Interior Secretary Ryan Zinke had refused to meet with them or convene a single meeting last year. The resignation of nine out of 12 National Park System Advisory Board members leaves the federal government without a functioning body to designate national historic or natural landmarks. It also underscores the extent to which federal advisory bodies have become marginalized under the Trump administration."
"House GOP leaders on Tuesday night pitched a new strategy to avert a looming government shutdown that includes children's health funding and the delay of ObamaCare taxes. Lawmakers need to pass a short-term stopgap bill by midnight Friday, when money for the federal government runs out. The latest GOP plan would keep the government’s lights on through Feb. 16, and be coupled with a six-year extension of funding for the popular Children's Health Insurance Program (CHIP). The continuing resolution or CR would also delay ObamaCare's medical device and Cadillac taxes for two years, and the health insurance tax for one year starting in 2019."
"A key Senate negotiator and White House official on Tuesday expressed little hope for an immigration deal this week but nonetheless predicted that Congress can avoid a government shutdown." Marc Short, the White House Capitol Hill liaison, said he's optimistic about a deal on DACA overall, but not this week. Senate Majority Whip John Cornyn also said he doubts an agreement can be made before week's end.