The liftoff of the Apollo 12 mission, the rocket of which was hit by lightning
Efforts to get humans into space have always been fraught with danger, which has been underscored by a number of disasters and near-disasters. One such near-disaster was the launch of the Apollo 12 mission to the moon on Nov. 14, 1969, in which the Saturn V rocket that was being used to get astronauts Charles Conrad, Richard Gordon, and Alan Bean to the moon was struck by lightning—twice.
"What the hell was that?" Gordon radioed to the ground after the first hit, which caused a major electrical disturbance, according to NASA. Twenty seconds later, another strike hit the spacecraft. "Okay, we just lost the platform gang," reported Conrad, "I don't know what happened here. We had everything in the world drop out."
After it became clear that they had been hit by lighting and after the spacecraft's electrical systems came back, astronaut Conrad radioed to the ground that "I think we need to do a little more all-weather testing," to which the person on the other end responded: "Amen."
The Apollo 12 exerience did lead to greater consideration of atmospheric electrical activity when launching spacecraft, according to the NASA, which produced an incident report (PDF) analysis the following year of what happened and how similar incidents could be minimized in future launches.
Above is the audio from NASA of the first five minutes after launch, including the two lightning strikes, and below that are photos from the mission's time on the moon.