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Corrected at 5:25 to reflect that Ferrer endorsed Espaillat.

The anti-incumbent super PAC that has been roiling safe-seat House primaries across the country announced Tuesday it would next try to defeat its biggest target yet: Rep. Charlie Rangel, D-N.Y.

Rangel has represented his Harlem-based seat for four decades and survived in 2010 despite an ethics scandal that resulted in his censure. This year, state Sen. Adriano Espaillat, a Latino, is challenging him in a redrawn, majority-Latino district. On Tuesday, the super PAC called the Campaign for Primary Accountability announced it would wade in against Rangel and on Espaillat's behalf.

"Adriano Espaillat represents a new generation and brings a fresh perspective sorely needed in Washington," the group said in a statement.

The super PAC called Rangel "a model of the long-term incumbent who becomes too comfortable with the special interests that infest Washington."

It is the second major boost Espaillat has received this week. On Monday, Fernando Ferrer, a leading New York Latino, endorsed also Espaillat.