Another man who's out of politics, likely for good, is former Rep. Scott McInnis (R-Colo.). After allegations of plagiarism, McInnis lost the GOP primary nod in Colorado's gubernatorial race to someone who later got 11 percent in the general election. That pretty much sums it up.
On the other hand, Nevada Republican Sharron Angle is down but not out. Losing to Sen. Majority Leader Harry Reid (D-Nev.) with the GOP wind at her back in a state with the highest unemployment rate in the country doesn't bode well for her chances of statewide election in the future, but Nevada is a quirky state, and it's a toss-up whether Sen. John Ensign (R) runs again in 2012. If he doesn't, or even if he does and faces a primary challenge, Angle could mount a serious campaign. Or Democrats would certainly like her to.
And who knows what Treasurer Alexi Giannoulias (D) will do in Illinois? He is only 34, so he could go away for a good decade, not work in a bank, and come back stronger and less tied to corrupt mobsters. But first he'll have to escape the taint of this year's bitterly negative Senate race, which it looks like he's already trying to do by making nice with Sen.-elect Mark Kirk (R).
Of course, politicians aren't known for going quietly. It's a good bet some of the above people won't get the hint sent to them by voters this year. And their losses this year may make them even more determined to correct their political obituary. Don't write the final lines of those just yet.